This review article deals with various aspects of the extrusion–spheronization technique. The first part includes different steps in the production process of pellets. Extrusion / spheronization is especially useful in producing dense granules for controlled release applications, but can be used for optimized immediate release . Spheronization has many advantages (link). The process is useful in several ways: it can improve the product; simplify manufacturing processes and help to.

Author: Kir Dur
Country: Albania
Language: English (Spanish)
Genre: Spiritual
Published (Last): 2 July 2008
Pages: 252
PDF File Size: 14.18 Mb
ePub File Size: 12.4 Mb
ISBN: 647-3-48891-290-8
Downloads: 4854
Price: Free* [*Free Regsitration Required]
Uploader: JoJozilkree

A Description of the Spheronization Process

Don’t miss these key speaking events:. Typically, the edges of cylindrical granules are epheronization most likely to break apart and generate dust during handling.

Just the way you need it. It is essential that this rope movement is present for an optimal spheronisation. The process consists of four process steps: In general, smaller particles require higher speed while bigger particles with higher mass which spheronizxtion in more force during a collision require lower speeds.

Types of Caleva Spheronizerx. Larger sizes would have a poor product appearance not round and a low yield of product and smaller sizes would be difficult to extrude.

In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications. The continuous collision of the particles with the wall and with the friction plate gradually turn the spheronisation segments into spheres, provided that the granules are plastic enough to allow the deformation without being destroyed.

Abstract This review article deals with various aspects of the extrusion—spheronization technique. The coated spheres may be used spheornization encapsulation, compression, or direct packaging into sachets or pouches for dosing.

Capsugel Dosage Form Solutions is offering a webinar that provides an overview of current taste masking approaches, with emphasis on two growing technology options. The technology chosen is dependent upon multiple active ingredient and formulation criteria, e.


Extrusion & Spheronization Pharmaceutical Technology

The spheronizatiln part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. The optimum charging volume depends upon the machine size and the product characteristics; there is an optimum batch size introduced into the spheronizer chamber that will produce the most narrow particle distribution and the best spheres.

The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result.

This dough then pressed through an extruder.

Under a Creative Commons license. In practice the optimum speed is determined by experimentation. The spheronization process allows considerable flexibility with most materials. Generally, extrudates up to 0.

The Spheronization Process

In some cases, the strong cohesive force in the extrudate prevent it from breaking into smaller pieces and therefore, more processing time is required. In other industries, the size of the pellets can be several centimeters.

Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies. The process is useful in several ways: In the final part, methods available for characterization particle size distribution, surface area, shape and sphericity, porosity, density, hardness and friability, flow properties, disintegration, and dissolution of the pellets are explained.

Elsevier About ScienceDirect Remote access Shopping cart Contact and support Terms and conditions Privacy policy We use cookies to help provide and enhance our service and tailor content and ads. The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts.

Spheronization has many advantages link. We also use cookies on our websites. This is most often crosshatched, but several sizes and other types are available.

For technical reasons, the resulting pellets are larger than micrometers. Capsugel offers a drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings.


The process is well known and widely used in the pharmaceutical industry but spheronization is becoming increasing recognized in other areas of industrial materials handling. The higher the speed, the more energy is imparted to the particle which results in more force during a collision. Graphical Abstract First, different steps such as granulation, extrusion, spheronization and drying of the extrusion—spheronization process are mentioned.

Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at feasibility, pilot and commercial scales. By clicking “I Agree”, you confirm that you are above the age of 16, that you have read and understood the Privacy Policy and the Cookies Policy, and that you agree to the collection, use and processing of your Personal Information by Lonza in accordance with said policies.

Extrudates are charged to the spheronizer and fall on the spinning disc. The spinning friction disc has a carefully designed groove pattern on the processing surface. At first, the cylindrical extrudate segments are cut into segments with a length ranging from 1 to 1. By continuing to use this website, you agree that we may store and access cookies on your device.

Extrusion / Spheronization

The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates. These segments then collide with the bowl wall and they are thrown back to the inside of the friction plate. Don’t miss these key speaking events: